Association of Serum LDL Cholesterol Level with Periodontitis among Patients Visiting a Tertiary-care Hospital

  • S Sharma Department of Periodontics, B.P. Koirala Institute of Health Sciences, Dharan
  • M Lamsal Department of Biochemistry, B.P. Koirala Institute of Health Sciences, Dharan
  • SK Sharma Deparyment of Internal Medicine, B.P. Koirala Institute of Health Sciences, Dharan
  • SR Niraula Department of Community Medicine, B.P. Koirala Institute of Health Sciences, Dharan
  • B Koirala College of Dental Surgery, B.P. Koirala Institute of Health Sciences, Dharan

Abstract

Introduction: High low-density lipoproteins (LDL) cholesterol is one of the major risk factors for cardiovascular disease. In recent years, some evidence has been presented that periodontitis,an infectious inflammatory condition of the periodontium, is associated with an increased risk of cardiovascular disease. To further elucidate this association, we have studied the levels of LDL cholesterol, a known risk marker for cardiovascular disease, in a periodontally-diseased group.

Methods: The levels of serum LDL cholesterol in 47 subjects with mild to severe (clinical attachment loss equal to or greater than 1 mm) chronic generalized (at least 30% of teeth affected) periodontitis with the mean age of 42.21 ± 1.46 years were measured and compared with those obtained from 42 age (39.83 ± 0.94) and sex matched controls. Both groups were free from systemic illnesses.

Results: The mean serum LDL cholesterol in periodontitis patients was found to be signifi cantly higher (P < 0.001) as compared to that of the controls. The mean clinical attachment loss was positively correlated with serum LDL cholesterol (P < 0.01) and gingival index (P<0.05). The frequency of persons with pathologic values of LDL cholesterol was signifi cantly higher in periodontitis patients compared with that of the controls.

Conclusions: These results showed that high serum LDL cholesterol may be associated with periodontitis in healthy people. However, it is unclear whether periodontitis causes an increase in the levels of serum LDL or an increased LDL is a risk factor for both periodontitis and cardiovascular disease.

Keywords: Cardiovascular disease, LDL cholesterol, periodontitis.

 

Published
2011-09-30
How to Cite
Sharma, S., Lamsal, M., Sharma, S., Niraula, S., & Koirala, B. (2011). Association of Serum LDL Cholesterol Level with Periodontitis among Patients Visiting a Tertiary-care Hospital. Journal of Nepal Medical Association, 51(183). https://doi.org/10.31729/jnma.10
Section
Original Article