Clinical grading of Intrahepatic Cholestasis Pregnancy

Authors

  • Meena Pradhan The first affiliated hospital of Chongqing Medical University
  • Yong SHAO The first affiliated hospital of Chongqing Medical University, Chongqing China

DOI:

https://doi.org/10.31729/jnma.1638

Abstract

Intrahepatic cholestasis of pregnancy (ICP) is the pregnancy induced liver disorder causing intense itching of palm, sole or even whole body especially in the evening at late second and third trimester. This disease categorized into mild and severe ICP according to raised level of LFT including serum level of Bile acid and Cholic acid. ICP has less morbidity to mother but significant risk for fetus in uterus. The predisposing element to cause intense pruritus is because of high amount of bile acid in maternal serum. Toxic bile acids affect fetal cardiomyocytes that retained in fetus body causing sudden intrauterine fetal death. ICP is commonly found in winter months and mostly itching of body occurs in the evening after sunset. Fetus in uterus is unsafe if mother’s bile acid exceeds normal value. ICP is successfully treated with Ursodeoxycholic acid (UDCA), S-adenosyl methionine (SAME), Dexamethasone and vitamin K. 

Keywords: itching; bile acid; obstetric cholestasis; Ursodeoxycholic cholic acid.

Author Biographies

Meena Pradhan, The first affiliated hospital of Chongqing Medical University

Obstetric and Gynecology

Yong SHAO, The first affiliated hospital of Chongqing Medical University, Chongqing China

Obstetrics and Gynecology

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Published

2013-06-30

How to Cite

Pradhan, M., & SHAO, Y. (2013). Clinical grading of Intrahepatic Cholestasis Pregnancy. Journal of Nepal Medical Association, 52(190). https://doi.org/10.31729/jnma.1638

Issue

Section

Review Article