Early Recognition of Fibrodysplasia Ossificans Progressiva-Important For the Clinician

  • Ankur Singh Maulana Azad Medical College, New Delhi, India.
  • Gaurav Pradhan Maulana Azad Medical College, New Delhi, India.
  • Chandravati Kumari Maulana Azad Medical College, New Delhi, India.
  • Seema Kapoor Maulana Azad Medical College, New Delhi, India.
Keywords: Fibrodysplasia ossificans progressiva; valgus deformity of greater toe.

Abstract

Fibrodysplasia ossificans progressiva is a rare disorder of heterotopic ossification. Procedures like biopsy and surgery are known to be aggravating factors in promoting heterotopic ossification Clues to clinical diagnosis may therefore be a great advantage to treating orthopedician. Valgus deformity of great toe is an important diagnostic clue for treating physicians and thus aids in preventing the clinicians from subjecting the patients to unnecessary invasive and traumatic procedures. Hence clinical clues to early diagnosis are important in establishing the correct diagnosis and directing future management. 
Keywords: fibrodysplasia ossificans progressiva; valgus deformity of greater toe. | PubMed

References

Connor JM, Evans DA. Genetics aspects of fibrodysplasia
ossificans progressive. J Med Genet. 1982;19(1) :35-9.
2. Rogers JG, Geho WB. Fibrodysplasia ossificans progressive.
A survey of forty cases. J Bone joint Surg.1979; 61(6A):909-14.
3. Park HS, Yoon CH, Kim HJ. The prevalence of congenital
inverted nipple. Aesthetic Plast Surg. 1999;23(2):144 –6.
4. Andre Leite Gonclaves, Marcelo R. Masruha, et al.
Fibrodysplasia ossificansprogressiva. Arq Neuropsiquiatr.
2005;63(4):1090-3.
5. Cohen RB, Hahn GV, Tabas J, et al. The natural history of
heterotopic ossification in patients who have fibrodysplasia
ossificans progessiva. J Bone Joint Surg Am. 1993:75(2):215-9.
6. Kussmaul WG, Esmail NA, Sagar Y, et al. Pulmonary and
cardiac functions in advanced fibrodysplasia ossificans
progressive. Clin Orthop. 1998:346:104-9.
7. Delai PLR. Kantanie S, Santili C, et al. Fibrodysplasia
ossificans progressive: a hereditary illness of multidisplinary
interest. Rev Bras Ortop. 2004;39: 205-13.
8. Shore EM, Xu M, Feldman GJ et al. A Recurrent mutation
in BMP type l receptor ACVR1causes inherited and
sporadic fibrodysplasia ossificans progressive. Nat Genet.
2006;38(5)525-7.
9. Nakajima M, Haga N, Takikawa K, Manabe N, Nishimura,
G, Ikegawa S. The ACVR1 617G-A mutation is also recurrent
in three Japanese patients with fibrodysplasia ossificans
progressiva. J Hum Genet. 2007; 52(5): 473-5.
Published
2016-06-30
How to Cite
Singh, A., Pradhan, G., Kumari, C., & Kapoor, S. (2016). Early Recognition of Fibrodysplasia Ossificans Progressiva-Important For the Clinician. Journal of Nepal Medical Association, 54(202), 91-93. https://doi.org/10.31729/jnma.2827
Section
Case Reports