TY - JOUR AU - Pradhan, Shaili AU - Mishra, P PY - 2009/04/01 Y2 - 2024/03/29 TI - Gingival Enlargement in Antihypertensive Medication JF - Journal of Nepal Medical Association JA - J Nepal Med Assoc VL - 48 IS - 174 SE - Original Article DO - 10.31729/jnma.232 UR - http://jnma.com.np/jnma/index.php/jnma/article/view/232 SP - 149-52 AB - <p>Introduction: Drug-induced gingival enlargement is a well documented side effect with the use <br />of phenytoin, cyclosporine and calcium channel blockers. The prevalence of gingival enlargement <br />induced by calcium channel blockers is uncertain. Several studies show confl icting results ranging <br />from 20% to 83%. This study was conducted to determine the prevalence of gingival enlargement in <br />patients taking antihypertensive medication. <br />Methods: All consecutive patients on antihypertensive agents attending the Dental OPD were <br />studied. The prevalence of drug induced gingival enlargement was determined. The periodontal <br />condition of all subjects were assessed including plaque index and probing depth. <br />Results: Total 81.2% of subjects taking antihypertensive were seen to have signifi cant enlargement. <br />Among them 71.1% were taking calcium channel blocker, 21.5% were taking ACE Inhibitors, and <br />7.4% were taking β- blockers. <br />Conclusions:Patients taking antihypertensive agents are at increased risk for gingival enlargement <br />and infl ammation is an important cofactor for the expression of this effect.<br />Key Words: anti-hypertensive drugs, gingival enlargement</p> ER -