SIGNIFICANCE OF COMPLEMENT PROFILE AND COMPLEMENT RECEPTOR 1 EXPRESSION IN RBC AND KIDNEY TISSUE IN IMMUNE COMPLEX MEDIATED DISEASE

Authors

  • Nirmal Baral B.P. Koirala Institute of Health Sciences, Dharan
  • M Lamsal B.P. Koirala Institute of Health Sciences, Dharan
  • L M Shrivastava All India Institute of Medical Sciences, New Delhi

DOI:

https://doi.org/10.31729/jnma.692

Abstract

A study was conducted to evaluate role of complement proteins and complement
receptor 1 (CR1) in pathogenesis of Systemic lupus erythematosus (SLE) and Immune
complex (IC) mediated glomerulonephritis. C3, C4, C3d and CH100 in serum, CR1 in
renal biopsies and RBC showed these parameters to be of great diagnostic and
prognostic values in Immune complex mediated diseases. Our study revealed an overall
decrease in levels of CR1, C3, C4 in IC mediated as compared to non - IC mediated
disease. Whereas C3d in case of SLE 247 ± 39 AU/L including IC mediated
Glomerulonephritis (ICGN) 208 ± 51 AU/L was found to be significantly increased
(P < 0.05) than normal control 46 ± 6 AU/L. There was no appreciable increase in
case of non - 1C mediated GN (61 ± 12 AU/L) CRI among SLE patients (261 ± 141/E)
and IC mediated group (270 ± 107/E) was found to be significantly lower (P < 0.05)
than normal control (627 ± 132/E) and non - IC GN (550 ± 86/E). C4 values among
SLE, patients were found to be 191 ± 104 mg/L as compared to control (286 ±110 mg/
L). The kidney biopsy of type III and type IV lupus nephritis revealed a complete
absence of CR1 in contrast to minimal change diseases. Thus this study revealed that
above parameters could be a valuable tool for distinguishing IC versus non-IC mediated
kidney diseases.

Key Words: Complement receptor 1 (CR1) Glomerulonephritis, SLE.

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Published

2003-01-01

How to Cite

Baral, N., Lamsal, M., & Shrivastava, L. M. (2003). SIGNIFICANCE OF COMPLEMENT PROFILE AND COMPLEMENT RECEPTOR 1 EXPRESSION IN RBC AND KIDNEY TISSUE IN IMMUNE COMPLEX MEDIATED DISEASE. Journal of Nepal Medical Association, 41(144), 481–484. https://doi.org/10.31729/jnma.692

Issue

Vol. 41 No. 144 (2002)

Section

Original Article

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